Large-scale synthesis of α-amino acid-N-carboxyanhydrides
نویسندگان
چکیده
منابع مشابه
Large-scale synthesis of α-amino acid-N-carboxyanhydrides
Heteroand homopolymers prepared from α-amino acid-N-carboxyanhydrides (NCAs) monomers are widely useful products. The preparation of pure NCA monomers has been extensively studied in the past. Purification methods including repeated crystallizations, extraction, and flash column chromatography have been devised. However, these methods are not easily amendable to large-scale NCA preparations. Th...
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Methodology has been developed for the general synthesis of optically active beta-amino acid N-carboxyanhydrides (beta-NCAs) through cyclization of N(beta)-Boc or N(beta)-Cbz beta-amino acids using phosphorus tribromide. The formation of beta-NCAs was confirmed by spectroscopy as well as an X-ray structural determination of beta-homoalanine-N-carboxyanhydride. The beta-NCA molecules could be po...
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ژورنال
عنوان ژورنال: Synthetic Communications
سال: 2016
ISSN: 0039-7911,1532-2432
DOI: 10.1080/00397911.2016.1249289